CIE Spotlight: Bad luck and cancer – Does evolution spin the wheel of fortune?

Beata U.
Beata U.

TitleBad luck and cancer: Does evolution spin the wheel of fortune?

Authors: Benjamin Roche, Beata Ujvari and Frédéric Thomas

Source: BioEssays (published online, 20 MAR 2015)

Brief summary of the paper: Cancer is a complex disease, with sophisticated cellular mechanisms as the targets of evolutionary processes driven by random genetic and epigenetic mutations.

Oncogenesis is evolutionarily linked to stem cell numbers/mutations and organ/body size; therefore, inter-disciplinary frameworks across different scales (cellular, tissue, organs and species) are necessary to decipher cancer progression.